21 episodesFirst aired 1 October 2025
In Season 11, Dr. Hannah Asher and Dr. Dean Archer navigate parenthood and an evolving relationship after discovering Archer is the father of her child. Meanwhile, the Gaffney medical staff faces severe crises, including a massive prison riot lockdown and dangerous house fires, while Goodwin battles boardroom politics and her ex-husband's worsening dementia. The E.D. staff faces unrelenting high-stress events. An all-night rave turns to tragedy, and a massive prison riot plunges the hospital into chaos, forcing the doctors to operate in unconventional spaces. Goodwin's job is put in jeopardy when she confronts Rabari's manipulation and clashes with Abrams over hospital staffing changes.
E1Oct 202543m
A family of victims from a house fire is rushed to Gaffney. Lenox fights to save two sisters injured in an all-night rave turned tragedy. Tensions mount between Goodwin and Abrams over difficult staffing changes.
E2Oct 202543m
Things get personal when Ripley and Archer butt heads over an unusual case. Asher makes a surprising discovery with an expectant couple. A patient throws the hospital into chaos.
E3Oct 202542m
Lenox and Frost receive an unusual request from the parents of a patient on life support. Ripley and Charles work with a man who can't remember who he is.
E4Oct 202543m
Charles races to convince a patient to accept treatment before it's too late. Frost bonds with a young girl battling immunodeficiency. Lenox makes a chilling discovery.
E5Oct 202543m
A personal clash between Asher and Archer reaches a breaking point. Charles and Ripley uncover a rare neurological disorder in a patient. Goodwin's personal life is put to the test.
E6Nov 202543m
Secrets are uncovered when Goodwin's family comes together for Bert. Ripley and Frost treat two children stung by hornets in a treehouse. A member of the team struggles with relationship woes.
E7Nov 202543m
Charles grows increasingly suspicious of a colleague's intentions. Lenox crosses a line to protect a patient. Asher and Archer treat a soon-to-be father battling cancer.
E8Jan 202643m
The doctors deal with the professional and personal fallout from the choices made during a city-wide power outage.
E9Jan 202643m
Tensions spike when a road rage incident sends three patients into the ED. Frost's former television co-star resurfaces. An unexpected arrival catches Asher and Archer off guard.
E10Jan 202643m
Archer and Frost confront a troubling medical mystery while treating a college basketball player. Lenox's treatment of a surrogate patient leads to unexpected complications for the patient and her best friend.
E11Jan 202643m
Old resentment stirs up Charles when his best friends from med school visit. Asher is forced to overcome obstacles in the treatment of one of her patients. Ripley looks to honor his best friend, Sully, on the one-year anniversary of his death.
E12Feb 202643m
Charles faces a new challenge when three medical students shadow him for a day. Goodwin faces a high-stakes board meeting. Frost reckons with his past.
E13Mar 202643m
The doctors at Gaffney are thrust into a race against time as they work to unravel a baffling medical mystery linked to the passenger jet, while lives hang in the balance. The crossover begins on Chicago Fire S14E13 Reckoning (I). It continues on Chicago P.D. S13E13 Reckoning (III).
E14Mar 202643m
Archer and Lenox treat two friends who were injured in St. Patrick's Day festivities. Hannah and Ripley treat a woman in the middle of a messy divorce.
E15Mar 202642m
Archer confronts his own mortality while on a complex case. One patient's quirky habit baffles Charles and Theo. A fatal diagnosis shocks one of the doctors at Gaffney.
E16Apr 202643m
Dr. Charles grapples with his own mental health following a harrowing experience working the suicide prevention line.
E17Apr 202643m
The doctors at Gaffney work to save one of their own in critical danger. Hannah finds herself at odds with the ob-gyn who will fill in for her maternity leave.
E18Apr 202643m
A horrific car accident puts a family's fate in the hands of the Gaffney staff. Ripley questions Lenox and her increasingly reckless behavior.
E19Apr 202643m
A patient's dangerous and complicated labor forces Hannah to confront her past. Lenox's brother Kip shows up at Gaffney asking her for her help with a co-worker who was injured on the job.
E20May 202643m
Gaffney is thrown into chaos when a prison riot overwhelms the E.D. Goodwin and Charles prepare for a high-stakes board meeting.
E21May 202642m
Hannah faces one of the most challenging deliveries of her career. Frost navigates demanding times.
